Research progress of vitamin D and tumor-related diseases

For decades, research on vitamin D has focused on the regulation of calcium and phosphorus metabolism. In recent years, vitamin D has been shown to have a wider range of biological effects, including inhibiting the proliferation of many types of cells, inducing apoptosis and differentiation, and regulating The function of the body's immune system. Michael et al [1] found that vitamin D receptors exist in most tissues and cells in the body and convert enzymes that convert 1,25 (OH) D in circulation into active 1,25 (OH) 2D3, It provides some new perspectives on the function of this vitamin. It plays an important role in reducing the incidence of some chronic diseases, including common tumors, autoimmune diseases, infectious diseases, and heart disease. Related studies have shown that 1,25 (OH) 2D3 can inhibit the proliferation of tumor cells and promote the differentiation of tumor cells. Many studies have found that 1,25 (OH) 2D3 and its analogues have an effect on prostate cancer, breast cancer, skin cancer and lung cancer. It can inhibit proliferation and promote apoptosis, and has a synergistic effect with other anti-tumor drugs to prevent tumor growth and metastasis.

1 Sources and metabolism of vitamin D

Vitamin D is both a vitamin and a steroid hormone. It is divided into two types: endogenous and exogenous. Endogenous is 7 in human skin.

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